Open AccessPreeclampsia in pregnancies with and without diabetes: the associations with placental weight. A population study of 655 842 pregnancies
Author(s) -
Dypvik Johanne,
StrømRoum Ellen M.,
Haavaldsen Camilla,
Vatten Lars J.,
Eskild Anne
Publication year - 2016
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1111/aogs.12795
Subject(s) - medicine , preeclampsia , decile , diabetes mellitus , obstetrics , gestational diabetes , pregnancy , population , birth weight , offspring , gestation , gynecology , endocrinology , biology , statistics , genetics , mathematics , environmental health
Women with diabetes are at increased risk of preeclampsia, and women with diabetes tend to deliver placentas and offspring that are large‐for‐gestational‐age. We therefore studied placental weight in preeclamptic pregnancies according to maternal diabetes status. Material and methods Information on all singleton births from 1999 through 2010 ( n = 655 842) were obtained from the Medical Birth Registry of Norway. We used z ‐scores of placental weight to adjust for differences in gestational age at birth between deliveries, and compared the distribution of placental weight z ‐scores, in deciles, in preeclamptic pregnancies with and without diabetes, and in non‐preeclamptic pregnancies with and without diabetes. Results Overall, the prevalence of preeclampsia was higher in pregnancies with diabetes than in pregnancies without diabetes (9.9% vs. 3.6%). Among preeclamptic pregnancies, having a placental weight in the highest decile was nearly three times more frequent (28.8%) in pregnancies with diabetes than in pregnancies without diabetes (9.8%). In the lowest decile, preeclamptic pregnancies with diabetes were underrepresented (7.5%), and preeclamptic pregnancies without diabetes were overrepresented (13.6%). Among pregnancies with preterm delivery, the above patterns were more pronounced, with 30.1% of the placentas in in preeclamptic pregnancies with diabetes in the highest decile, and 19.5% of the placentas in preeclamptic pregnancies without diabetes in the lowest decile. Conclusions These results suggest that women with diabetes who develop preeclampsia have a higher placental weight than other women with preeclampsia or non‐preeclamptic women.