Open AccessEffect of maternal and treatment‐related factors on the prevalence of birth defects after PESA ‐ ICSI and TESE ‐ ICSI : a retrospective cohort study
Author(s) -
Meijerink Aukje M.,
Oomen Reinoud E.,
Fleischer Kathrin,
IntHout Joanna,
Woldringh Gwendolyn H.,
Braat Didi D.M.
Publication year - 2015
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1111/aogs.12728
Subject(s) - medicine , intracytoplasmic sperm injection , obstetrics , odds ratio , confidence interval , retrospective cohort study , cohort study , gestational age , pregnancy , logistic regression , live birth , gynecology , in vitro fertilisation , surgery , biology , genetics
We performed a retrospective cohort study with the aim to evaluate the effect of maternal and treatment‐related factors on the prevalence of birth defects after intracytoplasmic sperm injection ( ICSI ) using percutaneous epididymal sperm aspiration ( PESA ) and testicular sperm extraction ( TESE ). Material and methods 643 newborns born after PESA ‐ ICSI ( n = 406) and TESE ‐ ICSI ( n = 237) in Radboud University Medical Center, after a gestational age of 12 weeks, 1 January 2002–1 January 2011 and 1 March–1 November 2014, respectively, were included in this study. Three sources of data were used for analysis: questionnaires, national obstetrics registration forms, and a lab‐database of all ICSI treatments. Data were analyzed using generalized estimating equations and logistic regression analysis. Results The prevalence of major birth defects in newborns born after PESA ‐ ICSI was 6.9% and after TESE ‐ ICSI was 5.9% (odds ratio 0.89, 95% confidence interval 0.46–1.75). No significant association was found between maternal or treatment‐related factors and the prevalence of birth defects. Conclusions We found a similar overall prevalence of birth defects in newborns born after PESA ‐ ICSI and TESE ‐ ICSI . The maternal and treatment‐related factors investigated did not show a significantly increased cumulative risk of birth defects.