Open AccessPolycystic ovary syndrome: cardiovascular risk factors according to specific phenotypes
Author(s) -
Aziz Mubeena,
Sidelmann Johannes J.,
Faber Jens,
Wissing MarieLouise. M.,
Naver Klara V.,
Mikkelsen AnneLis,
Nilas Lisbeth,
Skouby Sven O.
Publication year - 2015
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1111/aogs.12706
Subject(s) - medicine , insulin resistance , polycystic ovary , overweight , body mass index , obesity , endocrinology
Polycystic ovary syndrome ( PCOS ) is associated with obesity and insulin resistance. The objective of this cross‐sectional study was to investigate the impact of insulin resistance and body mass index ( BMI ) on inflammatory and hemostatic variables associated with long‐term risk of cardiovascular disease in women with PCOS . Material and methods 149 premenopausal women with PCOS were recruited consecutively from April 2010 to February 2012 at three Danish University Hospitals. The study was conducted at the Department of Gynecology and Obstetrics, Herlev University Hospital, Denmark. PCOS was diagnosed in accordance with the Rotterdam criteria and the women were classified into four phenotypes according to BMI and insulin resistance measured by the homeostasis model assessment of insulin resistance index. Body composition was determined by dual‐energy X‐ray absorptiometry. Main outcome measures were the biomarkers C‐reactive protein ( CRP ), plasminogen activator inhibitor‐1 ( PAI ‐1), and von Willebrand factor antigen. Results Normal weight insulin‐resistant PCOS women were characterized by abdominal obesity and elevated levels of plasma PAI ‐1. Overweight/obese insulin‐resistant PCOS women had increased levels of both PAI ‐1 and CRP . Of the three Rotterdam criteria, only hyperandrogenemia was significantly associated with the hemostatic risk marker of long‐term cardiovascular disease risk. Conclusions Surrogate risk markers for cardiovascular disease are elevated in women with PCOS , especially insulin‐resistant and overweight/obese women.