Open AccessAre repeated assisted reproductive technology treatments and an unsuccessful outcome risk factors for unipolar depression in infertile women?
Author(s) -
Sejbaek Camilla S.,
Pinborg Anja,
Hageman Ida,
Forman Julie L.,
Hougaard Charlotte Ø.,
Schmidt Lone
Publication year - 2015
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1111/aogs.12705
Subject(s) - medicine , depression (economics) , hazard ratio , proportional hazards model , danish , live birth , assisted reproductive technology , cohort , cohort study , risk factor , obstetrics , demography , pregnancy , infertility , confidence interval , linguistics , philosophy , genetics , sociology , biology , economics , macroeconomics
Previous studies have shown conflicting results as to whether unsuccessful medically assisted reproduction is a risk factor for depression among women. This study therefore investigated if women with no live birth after assisted reproductive technology ( ART ) treatment had a higher risk of unipolar depression compared with women with a live birth after ART treatment. Material and methods The Danish National ART ‐Couple ( DANAC ) Cohort is a national register‐based cohort study that consists of women who received ART treatment from 1 January 1994 to 30 September 2009, in Denmark ( n = 41 050). Information on unipolar depression was obtained from the Danish Psychiatric Central Research Register. The analyses were conducted in Cox regression analysis. Results During the 308 494 person‐years of follow up, 552 women were diagnosed with unipolar depression. A Cox proportional hazards model showed that women in ART treatment, with no live birth yet, had a lower risk of unipolar depression compared with women with a live birth. Women had the highest risk of unipolar depression 0–42 days after a live birth (adjusted hazard ratio 5.08, 95% CI 3.11–8.29) compared with women with no live birth. A lower, but still increased, risk of unipolar depression, was found in women 43 days to 1 year and >1 year after a live birth compared with women with no live birth yet. Conclusions Motherhood is an important trigger of unipolar depression in women conceiving after ART treatment.