Open AccessVitamin D and the risk of preeclampsia – a nested case–control study
Author(s) -
Gidlöf Sebastian,
Silva Aldo T.,
Gustafsson Sven,
Lindqvist Pelle G.
Publication year - 2015
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1111/aogs.12658
Subject(s) - preeclampsia , medicine , nested case control study , gestation , pregnancy , vitamin d and neurology , vitamin d deficiency , vitamin , obstetrics , gestational age , case control study , endocrinology , genetics , biology
We aimed to determine the relation between vitamin D deficiency in early pregnancy and preeclampsia. In a nested case–control study of 2496 pregnant women, we identified 39 women who developed preeclampsia and 120 non‐preeclamptic controls. Blood was sampled in 12th gestational week and analyzed for serum vitamin D. Vitamin D levels were similar in women who developed preeclampsia, 52.2 ± 20.5 nmol/L, and controls, 48.6 ± 20.5 nmol/L, p = 0.3. In addition, vitamin D deficiency (<50 nmol/L) was found in a similar proportion of control group (51.7%) as those with severe preeclampsia (41.2%). Women with vitamin D deficiency were 3 cm shorter than those with normal vitamin D levels ( p = 0.002). Our data do not support the hypothesis that vitamin D deficiency in early pregnancy is associated with preeclampsia, but we cannot rule out a relation later in gestation.