Open AccessThe obesity‐related FTO gene variant associates with the risk of recurrent miscarriage
Author(s) -
Andraweera Prabha H.,
Dekker Gustaaf A.,
Jayasekara Rohan W.,
Dissanayake Vajira H.W.,
Roberts Claire T.
Publication year - 2015
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1111/aogs.12640
Subject(s) - medicine , miscarriage , recurrent miscarriage , odds ratio , genotyping , body mass index , genotype , single nucleotide polymorphism , obstetrics , obesity , pregnancy , gynecology , genetics , gene , biology
Objective To investigate the association of the fat mass and obesity associated gene ( FTO ) rs9939609 single nucleotide polymorphism with recurrent miscarriage. Design Candidate gene association study. Setting Human Genetics Unit, Colombo, Sri Lanka. Population A total of 202 Sinhalese women with two or more first‐trimester miscarriages and no living children (cases) and 202 age‐ and ethnicity‐matched women with no history of miscarriage and having two or more living children (controls). Methods Peripheral blood was collected from the participants and DNA was extracted. Genotyping was performed at the Australian genome Research Facility using the Sequenom MassARRAY system. Genotype and allele frequencies of cases were compared with controls using chi‐squared testing. Main outcome measures The prevalence of the single nucleotide polymorphism in cases and controls. Results The mean age of the women in the recurrent miscarriage group was 31.9 ± 0.4 years and that of the control group was 32.3 ± 0.3 years. Of the women in the recurrent miscarriage group, 140 (69.3%) had experienced three or more first‐trimester miscarriages. The prevalence of the AA genotype [ p = 0.0002, odds ratio (95% CI) = 3.8 (1.8–8.0)] and A allele [ p = 0.002, odds ratio (95% CI) = 1.6 (1.2–2.2)] of the FTO rs9939609 single nucleotide polymorphism were increased in women in the recurrent miscarriage group compared with the control group. Conclusion The obesity‐related FTO rs9939609 single nucleotide polymorphism associates with recurrent miscarriage. This finding warrants further investigation with controlling for important factors such as body mass index, diabetes and cardiovascular disease status. The single nucleotide polymorphism may be useful in predicting the risk of recurrent miscarriage.