Open AccessPediatric ovarian neoplastic tumors: incidence, age at presentation, tumor markers and outcome
Author(s) -
Taskinen Seppo,
Fagerholm Riitta,
Lohi Jouko,
Taskinen Mervi
Publication year - 2015
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1111/aogs.12598
Subject(s) - medicine , germ cell tumors , incidence (geometry) , pathology , population , ovarian tumor , ovary , ovarian cancer , oncology , cancer , chemotherapy , physics , environmental health , optics
Objective To investigate the incidence, age of onset and tumor marker levels in benign and malignant pediatric ovarian neoplastic tumors. Design Retrospective database study. Setting Single‐center study. Population Forty‐five 0–15‐year‐old girls operated on for ovarian neoplastic tumors from the beginning of 1999 to the end of 2013. Methods Serum alpha‐fetoprotein, human chorionic gonadotropin and CA 125 levels as well as follow‐up data were recorded from patient charts and tumor histology was re‐evaluated. Main outcome measures Incidence of ovarian neoplastic tumors in the pediatric population. Differences in patient characteristics and tumor marker levels between those with benign and malignant tumors. Results The annual incidence of ovarian tumors was 2.2/100 000 females. Median age at presentation was 13.0 years (range 0.9–15.7), similar in both the 33 (73%) girls with a benign tumor and the 12 (27%) girls with a malignant tumor. The tumors with the highest propensity to metastasize (yolk sac tumors, mixed germ cell tumors, small cell carcinoma) were only found in girls > 9 years. Elevated serum alpha‐fetoprotein and CA 125 values associated more often with malignant tumors ( p < 0.001 and p < 0.031, respectively). There were no deaths or local recurrences. Four girls with a mature teratoma developed a contralateral benign ovarian tumor during follow up. Conclusions Both benign and malignant ovarian tumors are rare in the pediatric population, but the incidence increases with age. High alpha‐fetoprotein and CA 125 levels were associated with malignant tumors. The prognosis of the pediatric ovarian tumors seems to be favorable.