Open AccessOvarian preservation in young women with endometrial cancer of endometrioid histology
Author(s) -
Kinjyo Yoshino,
Kudaka Wataru,
Ooyama Takuma,
Inamine Morihiko,
Nagai Yutaka,
Aoki Yoichi
Publication year - 2015
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1111/aogs.12588
Subject(s) - medicine , endometrial cancer , metastasis , ovarian cancer , stage (stratigraphy) , gynecology , hysterectomy , lymph node , cancer , oncology , pathology , biology , paleontology
Objective To clarify the frequency and risk factors of ovarian metastasis in women with endometrial cancer of endometrioid histology. Design Retrospective observational study. Setting University of the Ryukyus Japan 1990–2011. Population Eighty‐eight women ≤45 years of age with endometrial cancer of only endometrioid histology. Methods Clinicopathological factors from the medical records were used. Fisher's exact test and logistic regression analysis were used to analyze predictive factors for ovarian metastasis. Main outcome measures Risk factors of ovarian malignancy. Results All women underwent total abdominal hysterectomy, bilateral salpingo‐oophorectomy and lymph node dissection. The median age was 39 years, and FIGO stage distributions were: stage I, 63 (71.6%) women; stage II , 14 (15.9%) women; and stage III , 11 (12.5%) women. Pathologically, ovarian metastasis was observed in four (4.5%) women. Only lymph node metastasis was a significant predictive factor for ovarian metastasis ( p = 0.0038), and deep myometrial invasion was the only significant factor ( p = 0.0085) for the prediction of lymph node metastasis. No ovarian malignancy was found in 72 women with invasion ≤50% myometrial depth and no enlargement of the ovaries. We observed ovarian metastasis in two (14.3%) of 14 women with deep myometrial invasion without ovarian tumor. Conclusion Ovarian preservation surgery might be considered in endometrial cancer of endometrioid histology with ≤50% myometrial depth invasion with no ovarian mass after taking into account family history.