Open AccessA prospective study of screening for hypertensive disorders of pregnancy at 11–13 weeks in a Scandinavian population
Author(s) -
Skråstad Ragnhild B.,
Hov Gunhild G.,
Blaas HarmGerd K.,
Romundstad Pål R.,
Salvesen Kjell Å.
Publication year - 2014
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1111/aogs.12479
Subject(s) - preeclampsia , medicine , gestational hypertension , obstetrics , pregnancy , gestational age , gestation , population , small for gestational age , prospective cohort study , uterine artery , receiver operating characteristic , gynecology , genetics , environmental health , biology
Objective To investigate the prediction of preeclampsia and gestational hypertension using maternal characteristics, mean arterial pressure ( MAP ), uterine artery pulsatility index (Ut API ), pregnancy‐associated plasma protein‐A ( PAPP ‐A) and placental growth factor (Pl GF ) at gestational weeks 11–13 in a Scandinavian population with a medium to high prior risk for developing hypertensive disorders of pregnancy. Design Prospective screening study. Setting National Center for Fetal Medicine, Trondheim, Norway. Population 579 women who were nulliparous or had a previous history of preeclampsia or gestational hypertension. Methods Women were examined between 11 +0 and 13 +6 weeks, with interviews for maternal characteristics and measurements of MAP , Ut API , PAPP ‐A and Pl GF . The tests were evaluated separately and in combined models with receiver operating characteristics ( ROC ) curves. Main outcome measures Prediction of preeclampsia, severe preeclampsia and gestational hypertension. Results The best model for severe preeclampsia ( MAP +Ut API +Pl GF + PAPP ‐A) achieved an area under the ROC curve of 0.866 [95% confidence interval (95% CI) 0.756–0.976]. The best models for preeclampsia ( MAP +Ut API +age) achieved 0.738 (0.634–0.841), gestational hypertension ( MAP ) 0.820 (0.727–0.913) and hypertensive disorders in pregnancy overall ( MAP +Pl GF +age) 0.783 (0.709–0.856). Using the best model we could identify 61.5% (95% CI 31.6–86.1) of severe preeclampsia, 38.5% (95% CI 20.2–59.4) of preeclampsia and 42.9% (95% CI 21.8–66) of gestational hypertension at a fixed 10% false‐positive rate. Conclusions Maternal characteristics, MAP , Ut API , PAPP ‐A and Pl GF showed limited value as screening tests. Further research on biochemical and biophysical tests and algorithms combining these parameters is needed before first trimester screening for hypertensive disorders of pregnancy is included in antenatal care in Scandinavia.