Open AccessAngiogenic factors and uterine Doppler velocimetry in early‐ and late‐onset preeclampsia
Author(s) -
Tobinaga Clarissa M.,
Torloni Maria R.,
GueuvoghlanianSilva Bárbara Y.,
Pendeloski Karen P.T.,
Akita Patrícia A.,
Sass Nelson,
Daher Silvia
Publication year - 2014
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1111/aogs.12366
Subject(s) - medicine , preeclampsia , uterine artery , soluble fms like tyrosine kinase 1 , endocrinology , plasminogen activator inhibitor 1 , adiponectin , plasminogen activator , gestation , pregnancy , insulin resistance , placental growth factor , diabetes mellitus , vascular endothelial growth factor , biology , genetics , vegf receptors
Objective To assess correlations between maternal serum levels of pro‐ and anti‐angiogenic factors with uterine perfusion in women with early‐ compared with late‐onset preeclampsia, and in healthy pregnant women. Design Case‐control study. Setting Antenatal care clinic located within a hospital (São Bernardo do Campo, Brazil). Population We enrolled 54 preeclamptic and 54 healthy control women who were coming for routine ultrasound at 28–36 weeks' gestation. Methods All participants had uterine artery and umbilical Doppler studies and a blood sample to assess maternal serum levels of soluble fms‐like tyrosine kinase‐1, soluble endoglin, adiponectin and plasminogen activator inhibitor‐1. All angiogenic factors were measured using enzyme‐linked immunosorbent assay. Main outcome measures Levels of pro‐ and anti‐angiogenic factors in maternal serum, and uterine artery Doppler findings. Results Concentrations of soluble fms‐like tyrosine kinase‐1 and soluble endoglin were significantly higher in preeclamptic than control women ( p < 0.0001 and p < 0.0001, respectively), especially in those with early‐onset (<34 weeks) preeclampsia. These two anti‐angiogenic mediators were significantly correlated with increased uterine artery Doppler in the preeclamptic women. Plasminogen activator inhibitor‐1 levels were significantly higher in preeclampsia ( p = 0.03) but unrelated to uterine artery resistance. Adiponectin levels were similar in cases and controls, independent of body mass index and unrelated to uterine artery resistance. Conclusion Preeclamptic patients have increased soluble fms‐like tyrosine kinase‐1 and soluble endoglin serum levels and this increase is directly correlated with uterine artery resistance, especially in those with early‐onset preeclampsia.