Open AccessOvarian granulosa cell tumor and increased risk of breast cancer
Author(s) -
Hammer Anne,
Lauszus Finn F.,
Petersen Astrid C.
Publication year - 2013
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1111/aogs.12252
Subject(s) - medicine , breast cancer , odds ratio , cancer , gynecology , oncology , retrospective cohort study , breast carcinoma , incidence (geometry) , neoplasm , obstetrics , pathology , physics , optics
Granulosa cell tumor of the ovary ( GCT ) is a rare neoplasm. The tumor often secretes estrogens and then presents at an earlier stage due to hormone‐related symptoms. GCT women are at increased risk of endometrial carcinoma, but there is only limited information about GCT s and potential association to other hormone‐related neoplasms such as breast cancer. We conducted a retrospective follow‐up study on 163 women with GCT . Medical records and histological sections were reviewed and a search in the pathology registry performed. Eight [95% confidence interval ( CI ); 3.4–15.8] GCT women were diagnosed with a breast neoplasm; one with Paget's disease of the nipple and seven with breast carcinoma. Based on calculations using incidence rates on breast cancer among Danish women, we would have expected 2.5 cases of breast cancer. The odds ratio was 3.3 (95% CI , 1.6–6.6), suggesting an increased risk of breast cancer in GCT women.