Open AccessHypermethylation of HOXA 10 gene in mid‐luteal endometrium from women with ovarian endometriomas
Author(s) -
Fambrini Massimiliano,
Sorbi Flavia,
Bussani Cecilia,
Cioni Riccardo,
Sisti Giovanni,
Andersson Karin L.
Publication year - 2013
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1111/aogs.12236
Subject(s) - endometriosis , luteal phase , infertility , endometrium , epigenetics , medicine , dna methylation , gynecology , andrology , methylation , gene , gene expression , follicular phase , biology , pregnancy , genetics
A decrease in HOXA 10 gene expression in eutopic mid‐secretory endometrium has been found in women with endometriosis‐associated infertility. Promoter hypermethylation of HOXA 10 is thought to be the leading mechanism for epigenetic gene regulation in patients with endometriosis. In our series we documented significantly higher HOXA 10 promoter methylation levels in women with ovarian endometriomas than in healthy controls during the mid‐luteal phase. Development of epigenetic‐based strategies for non‐surgical treatment of infertility related to ovarian endometriomas could be an attractive field of research in the coming years.