Open AccessDiagnostic accuracy of risk of malignancy index in predicting complete tumor removal at primary debulking surgery for ovarian cancer patients
Author(s) -
FagöOlsen Carsten L.,
Håkansson Fanny,
Antonsen Sofie L.,
Høgdall Estrid,
Lundvall Lene,
Nedergaard Lotte,
Engelholm Svend A.,
Høgdall Claus
Publication year - 2013
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1111/aogs.12127
Subject(s) - debulking , medicine , ovarian cancer , receiver operating characteristic , tumor debulking , malignancy , surgery , stage (stratigraphy) , confidence interval , chemotherapy , cancer , radiology , biology , paleontology
Ovarian cancer patients in whom complete tumor removal is impossible with primary debulking surgery ( PDS ) may benefit from neoadjuvant chemotherapy and interval debulking surgery. However, the task of performing a pre‐operative evaluation of the feasibility of PDS is difficult. We aimed to investigate whether the risk of malignancy index ( RMI ) was a useful marker for this evaluation. RMI and surgical outcome were investigated in 164 patients, 49 of whom had no residual tumor after PDS . The receiver operating characteristic curve showed an area under the curve of 0.72 (confidence interval: 0.64–0.80). The possibility of complete tumor removal decreased with increasing RMI and there was a tendency towards higher RMI in patients with residual tumor after PDS , but no single cut‐off value of RMI produced useful clinical predictive values. In conclusion, RMI alone is not an optimal method to determine whether complete tumor removal is possible with PDS .