Open AccessPlacental weight relative to birthweight in pregnancies with maternal diabetes mellitus
Author(s) -
StrømRoum Ellen M.,
Haavaldsen Camilla,
Tanbo Tom G.,
Eskild Anne
Publication year - 2013
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1111/aogs.12104
Subject(s) - medicine , odds ratio , obstetrics , decile , birth weight , diabetes mellitus , confidence interval , pregnancy , preeclampsia , population , endocrinology , biology , statistics , mathematics , environmental health , genetics
Objectives To study the association of maternal diabetes mellitus with placental weight, birthweight and placental weight‐to‐birthweight ratio. Design Population‐based study. Setting Medical Birth Registry of Norway. Population All singleton births in Norway during 1999–2008 ( n = 536 997). Methods We compared the distribution of placental weight z‐scores and placental weight‐to‐birthweight ratio between pregnancies with and without diabetes. The associations of diabetes with placental weight z‐scores were also estimated as odds ratios with and without adjustment for birthweight, maternal age, parity, preeclampsia, smoking and cesarean delivery. Main outcome measures Placental weight, birthweight and placental weight‐to‐birthweight ratio. Results Mean placental weight was 736.6 g in diabetic pregnancies and 672.1 g in non‐diabetic pregnancies. The corresponding birthweights were 3682.1 g and 3557.0 g. In diabetic pregnancies, 26.2% of the placentas were in the highest decile of placental weight z‐score, as compared with 9.7% in non‐diabetic pregnancies ( p < 0.001). The corresponding figures for being in the highest decile of placental weight‐to‐birthweight ratio were 18.2 and 9.9% ( p < 0.001). The crude odds ratio for having a placenta in the highest decile of placental weight z‐score was 3.29 (95% confidence interval 3.14–3.45) in diabetic pregnancies with non‐diabetic pregnancies as the reference. After adjustment for birthweight and other variables, the odds ratio was 2.42 (95% confidence interval 2.29–2.56). Conclusions In diabetic pregnancies, placental weight as well as placental weight relative to birthweight were higher than in non‐diabetic pregnancies.