Open AccessCord blood C‐peptide levels relate to the metabolic profile of women with and without gestational diabetes
Author(s) -
DUBÉ MARIECHRISTINE,
MORISSET ANNESOPHIE,
TCHERNOF ANDRÉ,
WEISNAGEL S. JOHN
Publication year - 2012
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1111/aogs.12005
Subject(s) - medicine , cord blood , gestational diabetes , endocrinology , insulin , c peptide , pregnancy , diabetes mellitus , offspring , body mass index , insulin resistance , gestation , biology , genetics
Plasma C‐peptide reflects the insulin‐secretory activity of pancreatic β‐cells which modulates fetal growth. Cord blood C‐peptide levels were measured in women with gestational diabetes mellitus (GDM) and in women with normal glucose tolerance (NGT). Forty‐one women underwent a 75‐g oral glucose tolerance test (18 GDM, 23 NGT). Cord blood C‐peptide ( p = 0.09) and glucose levels ( p = 0.08) from newborns of GDM women tended to be higher than those from NGT women. In the entire group, cord blood C‐peptide correlated with maternal insulin, fasting C‐peptide, insulin sensitivity, interleukin‐6, weight and body mass index measured at screening (ρ from 0.34 to 0.48, all p < 0.05) and tended to correlate with offspring weight (ρ = 0.28, p = 0.08). Newborns of GDM women tended to have elevated cord blood C‐peptide which correlated with maternal insulin, insulin sensitivity and anthropometric measures at diagnosis and with offspring characteristics. This suggests that insulin‐secretory activity of the newborn is related to maternal metabolic parameters.