Open AccessEffects of resveratrol on growth, antioxidative status and immune response of snakehead fish ( Channa argus )
Author(s) -
Tian Jiaxin,
Han Guanghong,
Li Ying,
Zhao Linhui,
Wang Guiqin
Publication year - 2021
Publication title -
aquaculture nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 79
eISSN - 1365-2095
pISSN - 1353-5773
DOI - 10.1111/anu.13290
Subject(s) - biology , malondialdehyde , superoxide dismutase , immune system , snakehead , lysozyme , catalase , antioxidant , resveratrol , endocrinology , glutathione peroxidase , medicine , zoology , andrology , oxidative stress , immunology , biochemistry , fish <actinopterygii> , fishery
To explore the effects of resveratrol (RES) supplemented in diet, growth performance, levels of antioxidant activities and immune parameters of Channa argus were determined. Six experimental diets were formulated, which contain RES levels within 0–125 mg/kg diet. After feeding trial, the results of growth performance showed that feeding more than 75 mg RES/kg diet could significantly promote C . argus special growth rate (SGR, p < .05). The level of malondialdehyde (MDA) was not significantly changed in C . argus fed with RES supplement diet ( p > .05). The levels of superoxide dismutase (SOD), catalase (CAT) and glutathione‐ S ‐transferase (GST) were significantly increased in tissues and serum of C . argus fed with RES supplement diet within 75–125 mg/kg ( p < .05). Similarly, total antioxidant capacity (T‐AOC) level was significantly increased in serum and tissues ( p < .05) except liver and kidney ( p > .05). Serum IgM level, important immune parameter, of 125 mg RES/kg diet was significantly higher than other doses ( p < .05). There was no significant difference in complement 3 (C3), C4 and lysozyme (LYZ) levels of serum and tissues fed with 100 and 125 mg RES/kg diet ( p < .05), and biochemical parameters related to immune responses were significantly increased. Moreover, qPCR results indicated that feeding 100 mg RES/kg diet could significantly upregulate immune gene expression in tissues ( p < .05), containing interleukin‐1β (IL‐1β), interleukin‐8 (IL‐8), interleukin‐10 (IL‐10) and tumour necrosis factor‐α (TNF‐α). For culturing C . argus , feeding diet supplemented with 125 mg RES might improve growth, antioxidative status and immune responses.