Open AccessEffect of different levels of dietary acidifier “sodium diformate” on the innate immune system and expression of growth and immunological related genes in Salmo trutta caspius
Author(s) -
Mohammadian Takavar,
Momeni Hossein,
Mesbah Mehrzad,
Tabandeh Mohammad Reza,
Khosravi Mohammad
Publication year - 2020
Publication title -
aquaculture nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 79
eISSN - 1365-2095
pISSN - 1353-5773
DOI - 10.1111/anu.13148
Subject(s) - biology , immune system , innate immune system , salmo , gene expression , gene , immunology , fish <actinopterygii> , biochemistry , fishery
Sodium diformate (SDF) is an organic acid that modulates growth performance, health and immunological properties. However, nowadays there is limited information available about the effects of SDF on innate immune system, growth performance and immune‐related gene expression. Due to the lack of information about this supplement, this study aimed to evaluate the effect of SDF on the innate immune system, growth and immune‐related gene expression. Salmo trutta caspius fed control or diet supplemented with different levels (0.5, 1 and 1.5 g/Kg) of SDF for 8 weeks. The results showed that T3 improved significantly ( p < .05) fish growth performance following 60 days of application, while T1 did not act ( p < .05). The results showed that dietary administration of SDF significantly ( p < .05) up‐regulated the expression of IGF‐1, FATP, γ‐GTP, IL‐1β and IL‐10. Also, elevated immune parameters were observed in S. t. caspius fed SDF supplemented the diet. The present results revealed beneficial effects of 1.5 g/Kg dietary SDF on immune response and growth up to 60 days. These results also highlighted the potential use of SDF (1.5 g/Kg) as additive in S. t. caspius diets but are not recommended in the long term when they culture in freshwater.