Open AccessEffects of dietary astaxanthin on the growth, innate immunity and antioxidant defence system of Paramisgurnus dabryanus
Author(s) -
Chen XiuMei,
Gao ChunShan,
Du XiaoYan,
Yao JinMing,
He FeiFei,
Niu XiaoTian,
Wang GuiQin,
Zhang DongMing
Publication year - 2020
Publication title -
aquaculture nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 79
eISSN - 1365-2095
pISSN - 1353-5773
DOI - 10.1111/anu.13093
Subject(s) - astaxanthin , hepatopancreas , antioxidant , biology , innate immune system , immunity , food science , immune system , biochemistry , immunology , carotenoid
The effects of astaxanthin supplementationon the growth, innate immunity and antioxidant defence system of loach ( Paramisgurnus dabryanus ) were investigated in this study. A total of 450 fish (initial average weights of 3.00 ± 0.10 g) were fed five diets with graded levels of astaxanthin (0.00, 50.00, 100.00, 150.00 and 200.00 mg/kg) for 56 days. The results showed that astaxanthin supplementation significantly stimulated the growth (FBW, WG, FER, HSI), innate immunity (AKP activity in the hepatopancreas, intestinal tract, muscle and skin and LZM activity in the hepatopancreas, intestinal tract and skin), antioxidant ability (T‐SOD, GSH‐PX and CAT activities and T‐AOC, GSH and MDA contents in the hepatopancreas, intestinal tract, muscle and skin) of loach. Moreover, dietary astaxanthin supplementation significantly up‐regulated the relative mRNA levels of Nrf2 and Maf , and down‐regulated the relative mRNA level of Keap1 in the hepatopancreas when the supplementation levels of astaxanthin were 50–200 mg/kg. In conclusion, the diets with 100–151.06 mg/kg astaxanthin supplementation were optimal for loach, which based on the growth, immunity and antioxidant‐related indicators, and the astaxanthin supplementation regulated the antioxidant ability partially referring to Keap1‐Nrf2 signallings.