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IMMUNOSUPPRESSIVE EFFECT OF MISOPROSTOL: A NEW SYNTHETIC PROSTAGLANDIN E 1 ANALOGUE
Author(s) -
WIEDERKEHR JULIO C.,
DUMBLE LYNETTE,
POLLAK RAYMOND,
MORAN MARK
Publication year - 1990
Publication title -
australian and new zealand journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 51
eISSN - 1445-2197
pISSN - 0004-8682
DOI - 10.1111/ans.1990.60.2.121
Subject(s) - misoprostol , medicine , prostaglandin e1 , bioavailability , in vivo , in vitro , pharmacology , lymphocyte , prostaglandin , heart transplantation , transplantation , mixed lymphocyte reaction , immunology , immune system , t cell , pregnancy , abortion , biochemistry , chemistry , genetics , microbiology and biotechnology , biology
Prostaglandins are reported to play an important regulatory role in cell‐mediated immunity. The immunosuppressive properties of a new synthetic oral prostaglandin e 1 analogue, misoprostol, were studied in vivo in a rat heterotopic cardiac allograft model, and in vitro in mixed lymphocyte reaction. The results show that parenteral misoprostol, alone or in combination with low dose cyclosporin immunosuppressive therapy, significantly prolonged cardiac allograft survival compared with appropriate controls. Oral misoprostol alone in this model did not allow for measurable cardiac allograft prolongation. In vitro misoprostol demonstrated significant dose–response inhibition of the mixed lymphocyte culture assay. It is concluded that new prostaglandin E 1 analogues with oral bioavailability may have important applications to clinical transplantation in man, and may be cyclosporin sparing.