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Serum carcinoembryonic antigen pre‐operative level in colorectal cancer: revisiting risk stratification
Author(s) -
Iacuzzo Cristiana,
Germani Paola,
Troian Marina,
Cipolat Mis Tommaso,
Giudici Fabiola,
Osenda Edoardo,
Bortul Marina,
de Manzini Nicolò
Publication year - 2021
Publication title -
anz journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.426
H-Index - 70
eISSN - 1445-2197
pISSN - 1445-1433
DOI - 10.1111/ans.16861
Subject(s) - medicine , carcinoembryonic antigen , colorectal cancer , cohort , retrospective cohort study , stage (stratigraphy) , oncology , receiver operating characteristic , risk stratification , cancer , gastroenterology , paleontology , biology
The present paper is a retrospective cohort analysis that we conducted to verify the prognostic role of pre‐operative serum carcinoembryonic antigen (CEA) level in predicting overall survival and risk of metastatic development in colorectal cancer patients. Although already evaluated by several studies, there is still lack of consensus in literature on the optimal cut‐off values which may allow for risk stratification and individualized treatments. Our results show that a pre‐operative CEA level >4.5 ng/mL correlated with a higher risk of developing distant recurrence in stage I, II and III colorectal cancer. Moreover, a pre‐operative CEA level >10 ng/mL was found to be significantly predictive of all‐cause mortality and poor disease‐free survival in patients with stage III and IV colorectal cancer undergoing potentially curative surgery.