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Comparison of ethanol concentrations after drinking in patients who underwent total gastrectomy versus healthy controls
Author(s) -
Honda Michitaka,
Hori Soshi,
Kobayashi Hiroshi,
Hamada Koichi,
Kawamura Hidetaka,
Nakayama Yujiro,
Todate Yukitoshi,
Miyakawa Teppei,
Takano Yoshinao,
Sato Atai,
Konno Shinichi
Publication year - 2021
Publication title -
anz journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.426
H-Index - 70
eISSN - 1445-2197
pISSN - 1445-1433
DOI - 10.1111/ans.16691
Subject(s) - medicine , gastrectomy , alcohol , gastroenterology , surgery , blood alcohol , alcohol consumption , cancer , poison control , injury prevention , emergency medicine , biochemistry , chemistry
Background The safety of drinking in patients who have undergone total gastrectomy for gastric cancer has not been established. We conducted a clinical trial to investigate the trend in alcohol absorption in actual patients. Methods Patients who received total gastrectomy with lymph‐node dissection and Roux‐en‐Y reconstruction six or more months ago were enrolled. Participants drank 1 unit (20 g) of ethanol within 1 h starting at least 1 h after a meal. The blood alcohol concentration (BAC) was then estimated by a measurement of the breath alcohol concentration. The peak and trend in the BAC in patients was compared with that in healthy volunteers who were matched with patients for the alcohol‐sensitive genotype. Results Ten patients and 10 healthy people were enrolled in the BAC evaluation. The peak BAC (%) was 0.158 in patients after total gastrectomy versus 0.110 in control ( P < 0.001). The mean half‐life of BAC was 58.0 min in the patient group and 94.0 min in the control group, although the mean time to complete drinking was significantly longer in the patient group than in the control group at 40.8 versus 21.9 min ( P = 0.009). Conclusion Drinking alcohol is likely to carry a risk of increasing the BAC in patients who have undergone total gastrectomy.