Premium
Postoperative serum procalcitonin versus C‐reactive protein as a marker of postoperative infectious complications in pancreatic surgery: a meta‐analysis
Author(s) -
Vasavada Bhavin,
Patel Hardik
Publication year - 2021
Publication title -
anz journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.426
H-Index - 70
eISSN - 1445-2197
pISSN - 1445-1433
DOI - 10.1111/ans.16639
Subject(s) - procalcitonin , medicine , diagnostic odds ratio , meta analysis , receiver operating characteristic , c reactive protein , area under the curve , odds ratio , gastroenterology , predictive value of tests , area under curve , surgery , sepsis , inflammation , pharmacokinetics
Background Aim of this meta‐analysis was to compare diagnostic accuracy C‐reactive protein and procalcitonin between postoperative days 3 and 5 to predict infectious complications post pancreatic surgery. Methods A systemic literature search was performed using MEDLINE, EMBASE and SCOPUS to identify studies evaluating the diagnostic accuracy of procalcitonin and C‐reactive protein to predict infectious complications between postoperative days 3 and 5 following pancreatic surgery. A meta‐analysis was performed using random‐effect model and pooled predictive parameters. Results Fifteen studies consisting of 2212 patients were included in the final meta‐analysis. Pooled sensitivity, specificity, area under curve and diagnostic odds ratio (DOR) for day 3 C‐reactive protein were 62%, 67%, 0.772 and 6.54, respectively. Pooled sensitivity, specificity, area under curve and DOR for day 3 procalcitonin were 74%, 79%, 0.8453 and 11.03, respectively. Sensitivity, specificity, area under the curve and DOR for day 4 C‐reactive protein were 60%, 68%, 0.8022 and 11.90, respectively. Sensitivity, specificity and DOR of postoperative day 5 procalcitonin level for predicting infectious complications were 83%, 70% and 12.9, respectively. Pooled sensitivity, specificity, Area Under Receiver Operating Curve and DOR were 50%, 70%, 0.777 and 10.19, respectively. Conclusion Postoperative procalcitonin is a better marker to predict postoperative infectious complications after pancreatic surgeries.