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Prognostic impact of tumour sidedness in patients with stage II colon cancer: a single‐centre retrospective study
Author(s) -
Iguchi Kenta,
Mushiake Hiroyuki,
Fukushima Tadao,
Rino Yasushi,
Masuda Munetaka
Publication year - 2021
Publication title -
anz journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.426
H-Index - 70
eISSN - 1445-2197
pISSN - 1445-1433
DOI - 10.1111/ans.16638
Subject(s) - medicine , hazard ratio , proportional hazards model , stage (stratigraphy) , confidence interval , univariate analysis , gastroenterology , oncology , retrospective cohort study , colorectal cancer , cancer , multivariate analysis , paleontology , biology
Background The search for high‐risk factors in stage II colon cancer (CC) is ongoing and several high‐risk factors for stage II CC have been identified; however, the effects of tumour sidedness on prognosis are not clear. This study aims to determine whether tumour sidedness could be identified as another high‐risk factor for stage II CC. Methods We retrospectively analysed 189 patients with stage II CC and compared clinicopathological findings and long‐term outcomes between the patients with right colonic cancer (RCC) and with left colonic cancer (LCC). Prognostic factors for survival were determined using univariate and Cox proportional regression analyses. Results A total of 72 patients were diagnosed with RCC and 117 patients were diagnosed with LCC. Patients with RCC were significantly older ( P < 0.001), and the number of harvested lymph nodes was greater in the RCC group (RCC: 25 versus LCC: 19; P = 0.003). The overall survival (OS) was worse in the RCC group than the OS in the LCC group (5‐year survival rate – RCC: 81.3% versus LCC: 90.4%; P = 0.025). Cox proportional regression analysis showed that tumour sidedness was an independent prognostic factor for both OS (hazard ratio (HR) 3.78, 95% confidence interval (CI) 1.61–8.85, P = 0.022) and DFS (HR 2.58, 95% CI 1.33–4.99, P = 0.005). Conclusion Patients with RCC have more negative prognostic factors and worse long‐term outcomes than those with LCC in stage II CC. Tumour sidedness is a high‐risk factor in stage II CC patients.