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Associations of novel inflammatory markers with long‐term outcomes and recurrence of diverticulitis
Author(s) -
Zager Yaniv,
Horesh Nir,
Dan Assaf,
Aharoni Mor,
Khalilieh Saed,
Cordoba Mordehay,
Nevler Avinoam,
Gutman Mordechai,
Rosin Danny
Publication year - 2020
Publication title -
anz journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.426
H-Index - 70
eISSN - 1445-2197
pISSN - 1445-1433
DOI - 10.1111/ans.16220
Subject(s) - medicine , diverticulitis , retrospective cohort study , neutrophil to lymphocyte ratio , gastroenterology , lymphocyte
Abstract Background The neutrophil‐to‐lymphocyte ratio (NLR) and platelet‐to‐lymphocyte ratio (PLR) have emerged as markers of various outcomes of inflammatory and malignant diseases. The association of those markers with short‐term outcomes of acute diverticulitis has been discussed in recent studies. This study aimed at evaluation of the association of NLR and PLR with long‐term outcomes in patients presenting with acute diverticulitis. Methods A retrospective single institute study included patients admitted with acute diverticulitis between 2012 and 2016. Associations were analysed of NLR and PLR values at admission with patient outcomes. Results A total of 456 patients were included in the study. High NLR and PLR values were associated with complicated disease ( P < 0.01 for both). Among patients with complicated diverticulitis, for those with high NLR, the interval to a recurrent episode of acute diverticulitis was shorter (68.3 days versus 83.7 days, P = 0.044). Patients with high NLR had higher mean number of readmissions (0.54 versus 0.34, P = 0.035). High NLR (10.06 ± 11.23 versus 7.6 ± 8.04, P = 0.012) and PLR (9.64 days ±10.56 versus 7.47 days ±8.225, P = 0.018) were associated with longer cumulative hospital stay due to acute diverticulitis. Conclusions High NLR and PLR values were associated with recurrence in acute diverticulitis in terms of shorter interval between recurrent episodes and longer cumulative hospitalization days.