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Effect of bile duct clamping versus no clamping on surgical site infections in patients undergoing pancreaticoduodenectomy: a randomized controlled study
Author(s) -
Singh Harjeet,
Krishnamurthy Gautham,
Kumar Hemanth,
Gorsi Ujjwal,
KumarM Praveen,
Mandavdhare Harshal,
Sharma Vishal,
Yadav Thakur D.
Publication year - 2020
Publication title -
anz journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.426
H-Index - 70
eISSN - 1445-2197
pISSN - 1445-1433
DOI - 10.1111/ans.15947
Subject(s) - medicine , pancreaticoduodenectomy , randomized controlled trial , surgery , bile duct , incidence (geometry) , antibiotic prophylaxis , biliary drainage , antibiotics , resection , physics , microbiology and biotechnology , optics , biology
Background Infectious complications cause significant morbidity after pancreatoduodenectomy (PD). The impact of uncontrolled spillage of bile during PD has not been systematically studied. Methods Patients undergoing PD for malignant lesions between March 2017 and May 2019 were considered for inclusion. All patients underwent standard pre‐operative preparation and antibiotic prophylaxis. After confirmation of resectability, the patients were randomized into one of the two groups: common hepatic duct clamping using atraumatic bulldog clamp after biliary division (Group I) or no clamping (Group II). Post‐operative outcomes including surgical site infection (SSI) were compared. Results Fifty‐two patients were assessed for eligibility and eventually 40 were randomized (median age: 53.5 years, 28 (70%) males). Twenty patients were randomized into each group and 14 in each group had undergone pre‐operative biliary drainage. Incidence of co‐morbidities, operative time and blood loss were comparable between the two groups. SSI was significantly lower in Group I (4 (20%) versus 11 (55%), P = 0.02). Number needed to treat to prevent one SSI was 3. Incidence of intra‐abdominal collections was higher in Group II, though, not statistically significant (2 (10%) versus 6 (30%), P = 0.23). The duration of post‐operative antibiotics was significantly higher in Group II (7 IQR 4 versus 11 IQR 7 days, P = 0.04). Among the risk factor evaluated in the entire population, higher incidence of SSI was seen in patients with positive bile culture (13 (65%) versus 2 (10%), P = 0.04). Conclusion Bile duct clamping during PD reduces risk of superficial SSI.