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Statin therapy does not influence the outcome of patients undergoing surgery for pancreatic cancer
Author(s) -
Karavias Dimitrios,
Thomas Paul,
Koh Amanda,
Irving Glen,
Navarro Alex P.,
Cameron Iain C.,
Gomez Dhanny
Publication year - 2020
Publication title -
anz journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.426
H-Index - 70
eISSN - 1445-2197
pISSN - 1445-1433
DOI - 10.1111/ans.15600
Subject(s) - medicine , pancreatic cancer , univariate analysis , statin , chemotherapy , surgery , adjuvant therapy , cancer , retrospective cohort study , multivariate analysis , lymphovascular invasion , gastroenterology , oncology , metastasis
Background Recently, statins have been associated with improved survival in certain cancers. The aim of this study was to evaluate the impact of statins on the outcome of patients undergoing surgery for pancreatic cancer. In addition, the effect of statins on the histopathological characteristics of the disease was assessed. Methods A retrospective review of the prospectively maintained hepato‐pancreatico‐biliary database was performed and patients with pancreatic cancer who underwent surgery between January 2014 and December 2017 were included. Statistical analysis was performed to assess the impact of statins on histopathological characteristics and survival outcome. Results A total of 151 patients were included, of whom 71 underwent pancreatic resections and 80 underwent trial dissection and bypass procedures. In the operated group, 20 patients were on statin therapy preoperatively. With respect to disease‐free survival, tumour size ( P = 0.023) and lymphatic invasion ( P = 0.015) were significant variables on univariate analysis. Gender ( P = 0.022), adjuvant chemotherapy ( P < 0.001), lymphatic invasion ( P = 0.021) and tumour size ( P = 0.041) were significant variables on univariate analysis with respect to overall survival. Multivariate analysis identified adjuvant chemotherapy as the only independent predictor of overall survival ( P < 0.001). No correlations between the use of statins and the histopathological characteristics were identified. Conclusion Adjuvant chemotherapy is an independent predictor of overall survival in patients undergoing surgery for pancreatic cancer. Statin therapy does not influence survival outcomes and histopathological characteristics following surgery for pancreatic cancer.