Premium
Clinical implications of the genetics of sporadic colorectal cancer
Author(s) -
Fischer Jesse,
Walker Logan C.,
Robinson Bridget A.,
Frizelle Frank A.,
Church James M.,
Eglinton Tim W.
Publication year - 2019
Publication title -
anz journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.426
H-Index - 70
eISSN - 1445-2197
pISSN - 1445-1433
DOI - 10.1111/ans.15074
Subject(s) - microsatellite instability , kras , colorectal cancer , medicine , dna mismatch repair , lynch syndrome , chromosome instability , disease , genetic testing , molecular genetics , genetic heterogeneity , bioinformatics , cancer , phenotype , oncology , genetics , biology , gene , microsatellite , allele , chromosome
Colorectal cancer (CRC) is common and at least 80% of cases are sporadic, without any significant family history. Prognostication and treatment have been relatively empirical for what has become increasingly identified as a genetically heterogeneous disease. There are three main genetic pathways in sporadic CRC: the chromosomal instability pathway, the microsatellite instability pathway and the CpG island methylator phenotype pathway. There is significant overlap between these complex molecular pathways and this limits the clinical application of CRC genetics. Recent Australian and New Zealand guidelines recommend routine testing of mismatch repair (MMR) status for new cases of CRC and selective KRAS and BRAF testing on the basis of diagnostic, prognostic and therapeutic implications. It is important that all clinicians treating CRC have an understanding of the importance of and basis for identifying key genetic features of CRC. It is likely that in the future better molecular characterization such as that allowed by the consensus molecular subtype classification will allow improved prognostication and targeted therapy in order to deliver more personalized treatment for CRC.