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Use of regional administration of prophylactic antibiotics in total knee arthroplasty
Author(s) -
Symonds Tristan,
Parkinson Ben,
Hazratwala Kaushik,
McEwen Peter,
Wilkinson Matthew,
Grant Andrea
Publication year - 2018
Publication title -
anz journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.426
H-Index - 70
eISSN - 1445-2197
pISSN - 1445-1433
DOI - 10.1111/ans.14816
Subject(s) - medicine , antibiotics , arthroplasty , dosing , antimicrobial , total knee arthroplasty , route of administration , antibiotic prophylaxis , intravenous antibiotics , surgery , intensive care medicine , anesthesia , chemistry , organic chemistry , microbiology and biotechnology , biology
Prosthetic joint infection after total knee arthroplasty is an infrequent, yet serious complication. Antimicrobial prophylaxis plays an important role in reducing the rate of surgical site infections. To be effective as an antimicrobial prophylaxis, the serum, tissue and bone concentrations of the antibiotic must be greater than the target organism's minimum inhibitory concentration. As antibiotic resistance increases current intravenous prophylactic dosing has been shown to be subtherapeutic for some patients. Intravenous regional administration and intraosseous regional administration of prophylactic antibiotics are novel methods used to increase the antibiotic tissue concentrations, which may enhance the efficacy of prophylactic antibiotics in total knee arthroplasty. Currently, literature has shown both intravenous regional administration and intraosseous regional administration to be safe and effective techniques. However, there is no clinical evidence to show that it results in a reduction of prosthetic joint infection rates. This study summarizes the current knowledge base on the use of regional administration of prophylactic antibiotics in total knee arthroplasty.