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Primary salivary gland malignancies: a review of clinicopathological evolution, molecular mechanisms and management
Author(s) -
Badlani James,
Gupta Ruta,
Balasubramanian Deepak,
Smith Joel,
Luk Peter,
Clark Jonathan
Publication year - 2018
Publication title -
anz journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.426
H-Index - 70
eISSN - 1445-2197
pISSN - 1445-1433
DOI - 10.1111/ans.14201
Subject(s) - salivary gland , medicine , pathology , identification (biology) , bioinformatics , biology , botany
Salivary gland cancers are a complex group of tumours with variations in location, type and grade, all of which influence their biological behaviour. The understanding of salivary gland pathology has evolved at the molecular level in the last decade leading to identification of distinct entities, development of improved methods of diagnosis as well as identifying therapeutic targets for selected high‐grade tumours. This article focuses on these advances and their impact on the management of primary salivary gland cancers.