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Prognostic value of positron emission tomography/computed tomography for adjuvant chemotherapy of colon cancer
Author(s) -
Baik HyungJoo,
Lee Seok Mo,
Seo Sang Hyuk,
An Min Sung,
Kim Kwang Hee,
Bae Ki Beom,
Oh Min Kyung,
Hong Kwan Hee
Publication year - 2018
Publication title -
anz journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.426
H-Index - 70
eISSN - 1445-2197
pISSN - 1445-1433
DOI - 10.1111/ans.14098
Subject(s) - medicine , positron emission tomography , standardized uptake value , stage (stratigraphy) , colorectal cancer , folfox , nuclear medicine , receiver operating characteristic , univariate analysis , fluorodeoxyglucose , cancer , chemotherapy , radiology , oncology , multivariate analysis , oxaliplatin , paleontology , biology
Background To assess the prognostic value of preoperative 18 F ‐fluorodeoxyglucose positron emission tomography/computed tomography in patients with high‐risk stage II or stage III colon cancer who underwent FOLFOX chemotherapy. Methods The study included 166 patients with high‐risk stage II or stage III colon cancer who received FOLFOX4 chemotherapy. Retrospective patient data were analysed including pathological stage, histology, disease‐free survival ( DFS ) and the maximum standardized uptake value ( SUV max ) of the primary tumour on 18 F ‐fluorodeoxyglucose positron emission tomography/computed tomography. The primary end point was DFS . Results There were recurrences in 29 of the 166 patients (17.4%). Measuring the area under the receiver operating characteristic curve, the cut‐off value of SUV max with maximum sensitivity and specificity was 10.95. Using the Kaplan–Meier method, the DFS of the patients categorized by SUV max tended to differ ( P = 0.055). In univariate analyses, the risk factors for DFS were age over 70 years, higher N stage and neural invasion. SUV max ≤ 10.95 showed a tendency, but was not significant ( P = 0.0604). In multivariate analyses, the risk factors for DFS were age over 70 and neural invasion. Conclusions The results of this study suggest that high fluorodeoxyglucose uptake of the primary mass in high‐risk stage II and stage III colon cancer does not significantly correlate with DFS .