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Treatment of peritoneal carcinomatosis with hyperthermic intraperitoneal chemotherapy in colorectal cancer
Author(s) -
Behrenbruch Corina,
Hollande Frédéric,
Thomson Benjamin,
Michael Michael,
Warrier Satish K.,
Lynch Craig,
Heriot Alexander
Publication year - 2017
Publication title -
anz journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.426
H-Index - 70
eISSN - 1445-2197
pISSN - 1445-1433
DOI - 10.1111/ans.14077
Subject(s) - medicine , colorectal cancer , peritoneum , metastasectomy , hyperthermic intraperitoneal chemotherapy , metastasis , peritoneal cavity , chemotherapy , peritoneal carcinomatosis , oncology , intraperitoneal chemotherapy , cancer , surgery , cytoreductive surgery , ovarian cancer
The peritoneum is the second most common site of metastasis after the liver and the only site of metastatic disease in approximately 25% of patients with colorectal cancer ( CRC ). In the past, peritoneal carcinomatosis in CRC was thought to be equivalent to distant metastasis; however, the transcoelomic spread of malignant cells is an acknowledged alternative pathway. Metastasectomy with curative intent is well accepted in patients with liver metastasis in CRC despite the paucity of randomized trials. Therefore, there is rationale for local treatment with peritonectomy to eliminate macroscopic disease, followed by hyperthermic intraperitoneal chemotherapy to destroy any residual free tumour cells within the peritoneal cavity. The aim of this paper is to summarize the current evidence for cytoreduction and hyperthermic intraperitoneal chemotherapy in the treatment of peritoneal carcinomatosis in CRC .