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Impact of operation timing on post‐operative infections following colorectal cancer surgery
Author(s) -
Li CaiXia,
An XiaoXia,
Zhao Bing,
Wu ShuiJing,
Xie GuoHao,
Fang XiangMing
Publication year - 2016
Publication title -
anz journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.426
H-Index - 70
eISSN - 1445-2197
pISSN - 1445-1433
DOI - 10.1111/ans.13471
Subject(s) - medicine , colorectal cancer , white blood cell , incidence (geometry) , surgery , cancer , cohort , cancer surgery , gastroenterology , physics , optics
Background To investigate the impact of operation timing on post‐operative infections in a cohort of patients undergoing colorectal cancer surgery. Methods We prospectively analysed surgical outcomes in patients who underwent colorectal cancer surgery at the F irst A ffiliated H ospital, C ollege of M edicine, Z hejiang U niversity, from J anuary to D ecember in 2014. In this non‐randomized trial, patients were divided into three groups according to the surgery start time: CT 1 (07:00 to 12:00 h), CT 2 (12:01 to 18:00 h), and CT 3 (18:01 h to midnight). The primary outcome was the proportion of patients developing infections within 4 weeks of the surgical procedure. Results Out of 756 patients that were enrolled in the study, 118 developed post‐operative infections. The results from blood and pus culture showed 97.1% specimen as being pathogen‐free. The overall incidence of post‐operative infection was 14.5% (38 of 262), 15.3% (46 of 300) and 17.5% (34 of 194) in the CT 1, CT 2 and CT 3 group, respectively, with no significant inter‐group differences. However, white blood cell counts, C ‐reactive protein and glucose levels at 24 h after the surgical procedure showed significant differences between the three groups (one‐way ANOVA , P < 0.05). Conclusion The occurrence of post‐operative infection in patients undergoing colorectal cancer surgery was not associated with operation timing. The expression of several inflammatory markers, such as white blood cell counts, C ‐reactive protein and blood glucose levels tended to correlate with the surgery start time.