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Preoperative radiation and free flap outcomes for head and neck reconstruction: a systematic review and meta‐analysis
Author(s) -
Herle Pradyumna,
Shukla Lipi,
Morrison Wayne A.,
Shayan Ramin
Publication year - 2015
Publication title -
anz journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.426
H-Index - 70
eISSN - 1445-2197
pISSN - 1445-1433
DOI - 10.1111/ans.12888
Subject(s) - medicine , surgery , radiation therapy , relative risk , meta analysis , head and neck , concordance , adverse effect , subgroup analysis , fistula , confidence interval
Background There is a general consensus among reconstructive surgeons that preoperative radiotherapy is associated with a higher risk of flap failure and complications in head and neck surgery. Opinion is also divided regarding the effects of radiation dose on free flap outcomes and timing of preoperative radiation to minimize adverse outcomes. Our meta‐analysis will attempt to address these issues. Method A systematic review of the literature was conducted in concordance to PRISMA protocol. Data were combined using STATA 12 and O pen M eta‐ A nalyst software programmes. Results Twenty‐four studies were included comparing 2842 flaps performed in irradiated fields and 3491 flaps performed in non‐irradiated fields. Meta‐analysis yielded statistically significant risk ratios for flap failure ( RR 1.48, P = 0.004), complications ( RR 1.84, P < 0.001), reoperation ( RR 2.06, P < 0.001) and fistula ( RR 2.05, P < 0.001). Mean radiation dose demonstrated a trend towards increased risk of flap failure, but this was not statistically significant. On subgroup analysis, flaps with >60 Gy radiation had a non‐statistically significant higher risk of flap failure ( RR 1.61, P = 0.145). Conclusion Preoperative radiation is associated with a statistically significant increased risk of flap complications, failure and fistula. Preoperative radiation in excess of 60 Gy after radiotherapy represents a potential risk factor for increased flap loss and should be avoided where possible.