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Prognostic factors in 151 patients with surgically resected non‐functioning pancreatic neuroendocrine tumours
Author(s) -
Song Ki Byung,
Kim Song Cheol,
Kim Ji Hoon,
Hong SeungMo,
Park KwangMin,
Hwang Dae Wook,
Lee Jae Hoon,
Lee YoungJoo
Publication year - 2014
Publication title -
anz journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.426
H-Index - 70
eISSN - 1445-2197
pISSN - 1445-1433
DOI - 10.1111/ans.12738
Subject(s) - medicine , neuroendocrine tumors , grading (engineering) , disease , oncology , multivariate analysis , lymph , mitotic index , survival rate , localized disease , pathology , cancer , mitosis , civil engineering , engineering , biology , microbiology and biotechnology , prostate cancer
Background Recently, non‐functioning pancreatic neuroendocrine tumors (NF‐PNETs) are increasing. It is important to know about the prognostic factors and long‐term survival rates in patients with NF‐PNET for the management of these diseases.Methods We retrospectively analysed the records of 151 patients with NF‐PNET who had pancreatic resection between January 1995 and December 2010. Result The 10‐year overall survival, disease‐specific survival and disease‐free survival rate of the patients who underwent surgery for NF‐PNET were 72.6%, 85.1% and 57.2% respectively. The three staging systems (2004 World Health Organization classification, 2006 European Neuroendocrine Tumor Society stages and 2010 grading system) showed comparable prognostic relevance in disease‐specific survival of patients with resected NF ‐ PNETs . Lymph nodes metastasis, high Ki ‐67 index and mitotic rate were the independent poor prognostic factors for disease‐specific survival in the patients with surgically resected NF‐PNET on multivariate analysis. Conclusion We suggested that the three staging systems accurately reflect the prognosis in disease‐specific survival of patients with resected NF ‐ PNETs . Presence of lymph nodes metastases and high Ki ‐67 index and mitotic rate were the independent poor prognostic factors after resection of NF‐PNET .