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Gastric cancer: A ustralian outcomes of multi‐modality treatment with curative intent
Author(s) -
Chen Yufei,
Awan Nida,
Haveman Jan Willem,
Apostolou Christos,
Chang David K.,
Merrett Neil D.
Publication year - 2016
Publication title -
anz journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.426
H-Index - 70
eISSN - 1445-2197
pISSN - 1445-1433
DOI - 10.1111/ans.12693
Subject(s) - medicine , modality (human–computer interaction) , cancer , artificial intelligence , computer science
Abstract Background Gastric cancer is one of the leading causes of cancer‐related deaths worldwide. Large Western trials have shown overall 5‐year survival rates of 36–47%. Surgical resection remains the mainstay of curative treatment. We report the outcomes at a single A ustralian centre. Methods We analysed a prospectively kept database of patients after gastric resection for adenocarcinoma at a tertiary A ustralian hospital. Disease‐specific survival ( DSS ) was considered the primary end‐point. Results One hundred and seventy‐three patients underwent gastrectomy with curative intent. Average age at diagnosis was 68, with 72% being male patients. One hundred patients had a total gastrectomy and 73 had subtotal. The average number of lymph nodes examined was 23. All patients were discussed in a multidisciplinary setting. Perioperative morbidity rate was 31%, with 3.5% 30‐day mortality. Five‐year DSS was 67.4% with 91.2%, 76.7% and 39.3% for stage 1, 2 and 3 disease, respectively. Five‐year overall survival considering death from any cause was 47.4%. Conclusion This large Australian single centre study shows outcomes equivalent to other Western series and approaches that of J apanese data. High survival figures can be achieved when gastrectomy is performed by an experienced institution through a multi‐modality approach with adequate staging, aggressive and appropriate resection and selective use of perioperative therapy.