Premium
Prognostic significance of epidermal growth factor receptor overexpression in pancreas cancer and nodal metastasis
Author(s) -
Perini Marcos Vinicius,
Montagnini Andre Luis,
Coudry Renata,
Patzina Rosely,
Penteado Sonia,
Abdo Emilio Elias,
Diniz Alessandro,
Jukemura Jose,
Cunha Jose Eduardo Monteiro
Publication year - 2015
Publication title -
anz journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.426
H-Index - 70
eISSN - 1445-2197
pISSN - 1445-1433
DOI - 10.1111/ans.12399
Subject(s) - medicine , perineural invasion , lymphovascular invasion , immunohistochemistry , pancreas , epidermal growth factor receptor , nodal , univariate analysis , pathology , oncology , metastasis , adenocarcinoma , survival analysis , cancer , pancreatic cancer , multivariate analysis
Background Identification of molecular markers in pancreatic adenocarcinoma ( PA ) has the potential to guide targeted therapy. The objective of this study is to determine the prognostic significance of epidermal growth factor receptor ( EGFR ) expression (membrane and cytoplasmic) in resected PA and its correlation with lymph node metastasis and survival. Methods EGFR overexpression was determined by immunohistochemistry, and the pattern of expression was compared between the primary tumour, adjacent normal pancreas and involved lymph nodes. Results A total of 88 patients had curative resection. No difference was found in mEGFR overexpression between tumoural and metastatic nodal tissues ( P = 0.28). Median overall survival time was 22.9 months. Overall cumulative 1‐, 3‐ and 5‐year survival was 48%, 20% and 18%, respectively. In positive mEGFR tumour expression, survival was 46% at 1 year, 8% at 3 years and 0% at 5 years ( P < 0.05). Univariate analysis showed that male gender, portal vein ( PV ) resection, perineural, lymphovascular and peri‐pancreatic invasion, positive margins and positive mEGFR expression in tumour tissue had worse survival. Multivariate analysis showed that male gender, PV resection, vascular and perineural invasion remained independent predictors of poor survival. Conclusion Positive mEGFR overexpression is associated with decreased survival; however, it is not an independent prognostic factor.