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Clinicopathologic features of solid variant papillary thyroid cancer
Author(s) -
Chang Hojin,
Kim Seok Mo,
Chun Ki Won,
Kim Bup Woo,
Lee Yong Sang,
Chang HangSeok,
Hong Soon Won,
Park Cheong Soo
Publication year - 2014
Publication title -
anz journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.426
H-Index - 70
eISSN - 1445-2197
pISSN - 1445-1433
DOI - 10.1111/ans.12307
Subject(s) - medicine , papillary thyroid cancer , malignancy , thyroid cancer , lymph node , thyroid , radiology , metastasis , cancer , pathology
Background Solid variant papillary thyroid cancer ( SVPTC ) is a rare type of thyroid malignancy whose clinical characteristics remain poorly defined. Therefore, we evaluated the characteristics of 14 patients with SVPTC treated at our institution. Methods Of the 6052 patients with papillary thyroid cancer ( PTC ) evaluated at our institution between J anuary 2008 and D ecember 2011, 14 (0.23%) had SVPTC and were analysed retrospectively. Results Of the 14 patients with SVPTC , two were men and 12 were women, with a mean age of 48.2 years (range: 33–72 years). The mean follow‐up period was 24 months (range: 8–36 months). All patients were assessed preoperatively by ultrasound‐guided fine needle aspiration cytology ( FNAC ), with the diagnosis confirmed by permanent pathology and immunohistochemical staining performed by a specialized endocrine pathologist. Only one patient was diagnosed with SVPTC by preoperative FNAC , whereas 11 (78.6%) were diagnosed with PTC or suspected of having PTC . The mean tumour size was 1.02 ± 0.30 cm, with all tumours less than 2.0 cm in diameter. The infiltrative tumour margins were observed in eight patients (57.1%) and the extrathyroidal invasion in seven (50.0%). The central lymph node metastases were found in five patients (35.7%), and the lateral lymph node metastasis in one (7.1%). No patient experienced tumour recurrence or distant metastasis during follow‐up. Conclusions Despite the small sample size and the short follow‐up period, our results indicate that SVPTC may not be as aggressive a subtype as previously thought.