Open AccessSuppression of amiodarone‐induced torsade de pointes by landiolol in a patient with atrial fibrillation‐mediated cardiomyopathy
Author(s) -
Takahashi Koji,
Yamashita Mina,
Sakaue Tomoki,
Enomoto Daijiro,
Uemura Shigeki,
Okura Takafumi,
Ikeda Shuntaro,
Takemoto Masafumi,
Utsunomiya Yutaka,
Hyodo Takashi
Publication year - 2021
Publication title -
annals of noninvasive electrocardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.494
H-Index - 48
eISSN - 1542-474X
pISSN - 1082-720X
DOI - 10.1111/anec.12842
Subject(s) - amiodarone , medicine , cardiology , qt interval , discontinuation , atrial fibrillation , sinus rhythm , cardioversion , anesthesia , antiarrhythmic agent , cardiomyopathy , ventricular tachycardia , heart failure , heart disease
An elderly Japanese woman developed acute decompensated heart failure caused by persistent atrial fibrillation (AF) and left ventricular systolic dysfunction. Approximately 6 days after starting intravenous administration of amiodarone (600 mg/day) for maintaining sinus rhythm after cardioversion of AF, electrocardiograms revealed a prolonged QT interval associated with torsade de pointes (TdP). The amiodarone‐induced TdP disappeared after intravenous administration of landiolol plus magnesium and potassium, without discontinuation of amiodarone or overdrive cardiac pacing, although the prolonged QT interval persisted. To the best of our knowledge, this is the first report that landiolol could be effective for amiodarone‐induced TdP.