Open AccessThe effect of idiopathic premature ventricular complexes on left ventricular ejection fraction
Author(s) -
Altıntaş Bernas,
Özkalaycı Flora,
Çinier Göksel,
Kaya İlyas,
Aktan Adem,
Küp Ayhan,
Onuk Raşit,
Özcan Sevgi,
Uslu Abdulkadir,
Akyüz Abdurrahman,
Atıcı Adem,
Ekinci Selim,
Akın Halil,
Yılmaz Mehmet Fatih,
Koç Şahbender,
Tanık Veysel Ozan,
Harbalıoğlu Hazar,
Barman Hasan Ali,
Afşin Abdülmecit,
Gümüşdağ Ayça,
Alibaşiç Hayrudin,
Karabağ Yavuz,
Cap Murat,
Baysal Erkan,
Tanboğa İbrahim Halil
Publication year - 2020
Publication title -
annals of noninvasive electrocardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.494
H-Index - 48
eISSN - 1542-474X
pISSN - 1082-720X
DOI - 10.1111/anec.12702
Subject(s) - medicine , ejection fraction , cardiology , nomogram , qrs complex , logistic regression , odds ratio , heart failure
Aim Current literature lacks a definitive threshold of idiopathic premature ventricular complex (PVC) burden for predicting cardiomyopathy (CMP). The main objective of the present study was to evaluate relationship between the PVC burden and left ventricular ejection fraction (LVEF). Method This multicenter, cross‐sectional study included 341 consecutive patients with more than 1,000 idiopathic PVC in 24 hr of Holter monitoring admitted to the cardiology clinics between January 2019 and May 2019 in the nineteen different centers. The primary outcome was the LVEF measured during the echocardiographic examination. Result Overall, the median age was 50 (38–60) and 139 (49.4%) were female. Percentage of median PVC burden was 9% (IQR: 4%–17.4%). Median LVEF was found 60% (55–65). We used proportional odds logistic regression method to examine the relationship between continuous LVEF and candidate predictors. Increase in PVC burden (%) (regression coefficient (RE) −0.644 and 95% CI −1.063, –0.225, p < .001), PVC QRS duration (RE‐0.191 and 95% CI −0.529, 0.148, p = .049), and age (RE‐0.249 and 95% CI −0.442, −0.056, p = .018) were associated with decrease in LVEF. This inverse relationship between the PVC burden and LVEF become more prominent when PVC burden was above 5%. A nomogram developed to estimate the individual risk for decrease in LVEF. Conclusion Our study showed that increase in PVC burden %, age, and PVC QRS duration were independently associated with decrease in LVEF in patients with idiopathic PVC. Also, inverse relationship between PVC burden and LVEF was observed in lower PVC burden than previously known.