Open AccessGenetic variants on chromosomes 7p31 and 12p12 are associated with abnormal atrial electrical activation in patients with early‐onset lone atrial fibrillation
Author(s) -
Seifert Mariam B.,
Olesen Morten S.,
Christophersen Ingrid E.,
Nielsen Jonas B.,
Carlson Jonas,
Holmqvist Fredrik,
Tveit Arnljot,
Haunsø Stig,
Svendsen Jesper H.,
Platonov Pyotr G.
Publication year - 2019
Publication title -
annals of noninvasive electrocardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.494
H-Index - 48
eISSN - 1542-474X
pISSN - 1082-720X
DOI - 10.1111/anec.12661
Subject(s) - snp , medicine , single nucleotide polymorphism , atrial fibrillation , sinus rhythm , cardiology , gastroenterology , genotype , genetics , gene , biology
Background Abnormal P‐wave morphology ( PWM ) has been associated with a history of atrial fibrillation ( AF ) in earlier studies. Although lone AF is believed to have substantial genetic basis, studies on associations between single nucleotide polymorphisms ( SNP ) linked to lone AF and PWM have not been reported. We aimed to assess whether SNP s previously associated with lone AF (rs2200733, rs13376333, rs3807989, and rs11047543) are also linked to P‐wave abnormalities. Methods Four SNP s were studied in 176 unrelated individuals with early‐onset lone AF (age at onset <50 years), median age 38 years (19–63 years), 149 men. Using sinus rhythm ECG , orthogonal PWM was classified as Type 1—positive in leads X and Y and negative in lead Z, Type 2—positive in leads X and Y and biphasic (−/+) in lead Z, Type 3—positive in lead X and biphasic in lead Y (+/−), and the remaining as atypical. Results Two SNP s were found to be significantly associated with altered P‐wave morphology distribution: rs3807989 near the gene CAV 1/ CAV 2 and rs11047543 near the gene SOX 5 . Both SNP s were associated with a higher risk of non‐Type 1 P‐wave morphology (rs3807989: OR = 4.8, 95% CI = 2.3–10.2, p < 0.001; rs11047543: OR = 4.7, 95% CI = 1.1–20.5, p = 0.04). No association was observed for rs2200733 and rs13376333. Conclusion In this study, the two variants rs3807989 and rs11047543, previously associated with PR interval and lone AF , were associated with altered P‐wave morphology distribution in patients with early‐onset lone AF . These findings suggest that common genetic variants may modify atrial conduction properties.