Can abnormal dispersion of ventricular repolarization be a predictor of mortality in arrhythmogenic right ventricular cardiomyopathy: The importance of Tp‐e interval

Abstract Background Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiomyopathy characterized by ventricular arrhythmias and specific ventricular pathology. Repolarization abnormalities, the significant contributor to life‐threatening arrhythmias and mortality, are frequently observed ECG changes in patients with ARVC. This study aimed to evaluate the changes in Tp‐e interval, Tp‐e/QT, Tp‐e/QTc ratio, and traditional electrocardiographic features of electrical dispersion in patients with ARVC. Methods A total of 105 participants were enrolled in the current study. The ARVC group consisted of 40 subjects (30 men, with a median of 35 (26–41) years), and the control group included of 65 age and sex‐matched individuals (42 men, with a median of 37 (24–45) years). The Tp‐e interval, Tp‐e/QT ratio, and Tp‐e/QTc ratio were measured by the 12‐lead electrocardiogram. Results Tp‐e interval, cTp‐e interval, Tp‐e/QT, and Tp‐e/QTc ratio were significantly higher in ARVC patients compared to the control group (all p  < 0.001). Tp‐e interval, cTp‐e interval, Tp‐e/QT ratio, and Tp‐e/QTc ratio were significantly increased in deceased ARVC patients compared to the survival group ( p  = 0.038, p  < 0.001, p  = 0.006, p  = 0.032, respectively). In the multivariate analysis, RV‐FAC and cTp‐e interval level ( p  < 0.05 for each parameter) were associated with all‐cause mortality [odds ratio 1.747 95% CI (1.012–3.018); p  = 0.045 and odds ratio 1.166, 95% CI (1.017–1.336); p  = 0.027, respectively]. Conclusion Tp‐e interval, cTp‐e interval, Tp‐e/QT ratio, and Tp‐e/QTc ratio were prolonged in patients with NC. We revealed that abnormal dispersion of ventricular repolarization suggests the increased risk of mortality in ARVC.