Open AccessTWARMI pilot trial: The value and optimal criteria of microvolt T‐wave alternans in the diagnosis of reversible myocardial ischemia in patients without structural cardiac disease
Author(s) -
Puljevic Mislav,
DanilowiczSzymanowicz Ludmila,
Molon Giulio,
Puljevic Davor,
Raczak Grzegorz,
Canali Guido,
Velagic Vedran,
PezoNikolic Borka,
Milicic Davor
Publication year - 2019
Publication title -
annals of noninvasive electrocardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.494
H-Index - 48
eISSN - 1542-474X
pISSN - 1082-720X
DOI - 10.1111/anec.12610
Subject(s) - medicine , t wave alternans , cardiology , coronary artery disease , ischemia , electrocardiography , sudden cardiac death
Aims Microvolt T‐wave alternans (MTWA) testing is a beat‐to‐beat fluctuation in the amplitude of T wave. We investigated whether: (a) MTWA can be new non‐invasive tool for detection of reversible ischemia in patients with suspected CAD without structural heart disease, (b) MTWA can detect ischemia earlier and with greater test accuracy compared with exercise ECG ST‐segment testing, and (c) threshold value of MTWA and heart rate at which the alternans is estimated can be different compared to standard values. Methods A total of 101 patients with suspected stable coronary disease, but without structural heart disease, were included. Echocardiography, exercise ECG test, MTWA with classical and modified threshold alternans values, and coronary angiography were performed. Results About 33.3% patients had a false‐positive result on exercise ECG test. The sensitivity of exercise ECG ST‐segment test in the detection of coronary artery disease was 97.8%, and the specificity was 42.5% (DOR 33.89). In a group of angiographically positive patients, standard MTWA accurately identified 60% of patients, while 40% had a false‐negative result. About 91.8% patients with negative angiography result were accurately identified with 8.2% false positives. The sensitivity of MTWA was 59.61% and specificity 91.83%. Best ratio of sensitivity and specificity (86.53% and 95.91%, DOR 151.06) had modified criteria for positive MTWA (MTWA >1.5 µV at heart rate 115–125/min). Conclusions This study showed that MTWA can be the new non‐invasive tool for the detection of reversible ischemia in patients with suspected CAD without structural heart disease. Also, MTWA can detect ischemia earlier and with greater accuracy compared with exercise ECG testing.