Open AccessECG ‐derived Cheyne‐Stokes respiration and periodic breathing in healthy and hospitalized populations
Author(s) -
Tinoco Adelita,
Drew Barbara J.,
Hu Xiao,
Mortara David,
Cooper Bruce A.,
Pelter Michele M.
Publication year - 2017
Publication title -
annals of noninvasive electrocardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.494
H-Index - 48
eISSN - 1542-474X
pISSN - 1082-720X
DOI - 10.1111/anec.12462
Subject(s) - medicine , ambulatory , acute coronary syndrome , emergency department , cheyne–stokes respiration , cardiology , electrocardiography , heart failure , emergency medicine , myocardial infarction , psychiatry
Background Cheyne‐Stokes respiration ( CSR ) has been investigated primarily in outpatients with heart failure. In this study we compare CSR and periodic breathing ( PB ) between healthy and cardiac groups. Methods We compared CSR and PB , measured during 24 hr of continuous 12‐lead electrocardiographic ( ECG ) Holter recording, in a group of 90 hospitalized patients presenting to the emergency department with symptoms suggestive of acute coronary syndrome ( ACS ) to a group of 100 healthy ambulatory participants. We also examined CSR and PB in the 90 patients presenting with ACS symptoms, divided into a group of 39 (43%) with confirmed ACS , and 51 (57%) with a cardiac diagnosis but non‐ ACS . Super ECG software was used to derive respiration and then calculate CSR and PB episodes from the ECG Holter data. Regression analyses were used to analyze the data. We hypothesized Super ECG software would differentiate between the groups by detecting less CSR and PB in the healthy group than the group of patients presenting to the emergency department with ACS symptoms. Results Hospitalized patients with suspected ACS had 7.3 times more CSR episodes and 1.6 times more PB episodes than healthy ambulatory participants. Patients with confirmed ACS had 6.0 times more CSR episodes and 1.3 times more PB episodes than cardiac non‐ ACS patients. Conclusion Continuous 12‐lead ECG derived CSR and PB appear to differentiate between healthy participants and hospitalized patients.