Open AccessIncidence of Atrial Fibrillation following Alcohol Septal Ablation for Hypertrophic Cardiomyopathy
Author(s) -
Moss Travis J.,
Zipse Matthew M.,
Krantz Mori J.,
Sauer William H.,
Salcedo Ernesto E.,
Schuller Joseph L.
Publication year - 2016
Publication title -
annals of noninvasive electrocardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.494
H-Index - 48
eISSN - 1542-474X
pISSN - 1082-720X
DOI - 10.1111/anec.12335
Subject(s) - medicine , alcohol septal ablation , cardiology , hypertrophic cardiomyopathy , atrial fibrillation , mitral regurgitation , incidence (geometry) , ventricular outflow tract , cardiomyopathy , population , heart failure , obstructive cardiomyopathy , physics , optics , environmental health
Background Patients with hypertrophic cardiomyopathy (HCM) are at a fourfold to sixfold higher risk of developing atrial fibrillation (AF) compared to the general population, though incidence rates among patients undergoing alcohol septal ablation (ASA) are not well characterized. The purpose of this study was to evaluate atrial fibrillation incidence following ASA. Methods We studied 132 consecutive HCM patients without comorbid AF that underwent 154 ASA procedures. The incidence of AF in follow‐up was assessed through chart abstraction including electrocardiography. Survival free of AF was estimated using Kaplan‐Meier methodology. Results Over a mean follow‐up of 3.6 ± 2.7 years (maximum 11.3 years), 10 (7.6%) patients developed new‐onset AF. Of those who developed AF, both resting and provoked left ventricular outflow tract (LVOT) gradients had improved significantly (difference –79.78 mm Hg, P ≤ 0.005). Severity of mitral regurgitation improved in 7 (70%) patients. Survival free of AF was estimated to be 99.1%, 93.7%, and 91.7% at 1, 3, and 5 years. Conclusions Despite relieving LVOT obstruction and improving mitral regurgitation severity via ASA, new‐onset AF remained a common complication of hypertrophic cardiomyopathy.