Open AccessAssessment of Inhomogeneities of Repolarization in Patients with Systemic Lupus Erythematosus
Author(s) -
Avci Ahmet,
Demir Kenan,
Altunkeser Bulent Behlul,
Yilmaz Sema,
Yilmaz Ahmet,
Ersecgin Ahmet,
Demir Tarik
Publication year - 2014
Publication title -
annals of noninvasive electrocardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.494
H-Index - 48
eISSN - 1542-474X
pISSN - 1082-720X
DOI - 10.1111/anec.12145
Subject(s) - medicine , repolarization , cardiology , lupus erythematosus , immunology , antibody , electrophysiology
Objectives Systemic lupus erythematosus (SLE) is a chronic disease that affects many organ systems and manifests a broad spectrum of laboratory and clinical features. SLE patients have an increased risk of developing cardiovascular disease. The aim of this study was to evaluate inhomogeneities of repolarization by using T peak –T end (Tp–e) interval and Tp–e/QT ratio were measured from the 12‐lead surface electrocardiogram (ECG) in patients with SLE. Material and method This study included 69 SLE patients (69 females; mean age 35.8 ± 10.2) and 57 control subjects (57 females; mean age 34.5 ± 8.9). Transthoracic echocardiographic examination was done in all participants. QT parameters, Tp–e intervals and Tp–e/QT ratio were measured from the 12‐lead ECG. These parameters were compared between groups. Results No statistically significant difference was found between two groups in terms of basic characteristics. Diastolic function parameters were similar between the two groups (P > 0.05). In electrocardiographic parameters analysis, QT dispersion (QTd) and corrected QT dispersion (cQTd) were significantly increased in SLE patients compared the control group (49.5 ± 16.4 ms vs. 32.8±11.7 ms and 56.7 ± 19.5 ms vs. 36.4 ± 13.1 ms, all P value < 0.001). Tp–e interval and Tp–e/QT ratio were also significantly higher in SLE patients (82.8 ± 18.9 vs. 72.4 ± 17.6 and 0.22 ± 0.05 vs. 0.19 ± 0.05, P = 0.002 and P = 0.001, respectively). Tp–e interval and Tp–e/QT were positively correlated with disease duration (r = 0.29, P = 0.01 and r = 0.24, P = 0.04, respectively). Conclusion Our study revealed that QTd, cQTd, Tp–e interval and Tp–e/QT ratio increased in patients with SLE. Also, Tp–e interval and Tp–e/QT were positively correlated with disease duration.