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Introduction
Author(s) -
Schusterova
Publication year - 1967
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/ane.1967.43.s27.13
Subject(s) - citation , computer science , information retrieval , library science , psychology , world wide web
Background: Epicardial adipose tissue (EAT) is the visceral fat depot of the heart and is commonly increased in obese subjects. EAT is related to cardiovascular risk factors in adults. but this relationship in children is not well known yet. Aim of our study was to assess amount of EAT – measure by echocardiography and its association with cardiometabolic risk factors in obese and overweight children Study group and methods: Our study group consisted of 25 (mean age 12.96 ±2.28) obese and overweight subjects and 24 ageand gender matched lean controls. Blood pressure and waist circumference (WC) were measured and lipids levels, uremic acid, and total proteins levels were established. Each subject underwent transthoracic echocardiogram to evaluate EAT thickness. Results: In obese and overweight EAT was significantly higher (p<0.01) compared to normal weight control group. Obese and overweight children had significantly higher body weight (BW), BMI and waist circumference (WC) (p < 0.01). TAG, LDL and total cholesterol (p < 0.05; p < 0.01), systolic and diastolic blood pressure (BP) (p < 0.05; p < 0.01). Serum HDL cholesterol was lower (p < 0.05). In linear regression analysis EAT positively correlated with BW, BMI, WC and with systolic and diastolic BP, TAG (p < 0.01), and uric acid (UA) (p < 0.01). Negative correlation between HDL (p < 0.01) and EAT was found. Multiple regression analysis confirmed that body weight, BMI, BMI percentil and WC, systolic BP and TAG were the strongest independent variables correlated with EAT. Conclusion: Elevated echocardiographic EAT thickness in obese and overweight children is associated with unfavourable cardiometabolic risk profile. The echocardiographic measurement of EAT is a relatively reliable method in paediatric population. However, it requires the creation of a standardized examination methodology for children age, as well as the creation of certain reference values considering the growth and development of children, their gender as well as the puberty period characterized by hormonal changes different in girls and boys.