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Large hemorrhagic stroke after ChAdOx1 nCoV‐19 vaccination: A case report
Author(s) -
Mélo Silva Mário L.,
Lopes David P.
Publication year - 2021
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/ane.13505
Subject(s) - medicine , stroke (engine) , context (archaeology) , thrombosis , chills , aspirin , headaches , digital subtraction angiography , vomiting , surgery , angiography , mechanical engineering , paleontology , engineering , biology
Background The anti‐COVID‐19 vaccines are new, and we should be alert of potential adverse effects of them. Aims of the Study To report a case of a large hemorrhagic stroke 5 days after ChAdOx1 nCoV‐19 vaccination. Methods Clinical, imaging, and laboratory data of a patient with stroke admitted to our emergency department. Results A woman, 57 years old, took the first dose of the ChAdOx1 nCoV‐19 vaccine and shortly thereafter presented mild systemic symptoms and started on aspirin. On day 5, she had a sudden onset of sweating and paleness, which has followed by left hemiparesis, vomiting, and somnolence. Computed tomography showed a large right deep frontal lobe parenchymal hematoma with the inundation of the entire ventricular system. Platelets count, fibrinogen, prothrombin time, and D‐dimer were normal. Digital subtraction angiography did not show any signs of thrombosis or aneurysms in brain circulation. Conclusions Clinicians should be aware of cerebrovascular adverse effects of ChAdOx1 nCoV‐19, including out‐of‐context of vaccine‐induced immune thrombotic thrombocytopenia.