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Increased level of LIGHT/TNFSF14 is associated with survival in aneurysmal subarachnoid hemorrhage
Author(s) -
Schranz Daniel,
Molnar Tihamer,
ErdoBonyar Szabina,
Simon Diana,
Berki Tímea,
Nagy Csaba,
Czeiter Endre,
Buki Andras,
Lenzser Gabor,
Csecsei Peter
Publication year - 2021
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/ane.13394
Subject(s) - medicine , oncostatin m , gastroenterology , subarachnoid hemorrhage , tumor necrosis factor alpha , incidence (geometry) , interleukin 6 , pathology , cytokine , physics , optics
Objectives Multiple cytokines have been implicated in aneurysmal subarachnoid hemorrhage (aSAH), but tumor necrosis factor superfamily 14 (LIGHT/TNFSF14) and oncostatin‐M (OSM) have not been previously explored. Aims of the Study The primary objective of this study was to examine the relationship between TNFSF14 and OSM levels and survival. Our secondary goal was to investigate a potential association between these markers and the incidence of delayed cerebral ischemia (DCI). Materials & Methods We consecutively recruited 60 patients with a clinical diagnosis of aSAH. LIGHT/TNFSF14 and OSM serum concentrations were determined by ELISA. The primary endpoint was survival at Day 30, while development of DCI was assessed as secondary outcome. Results Patients had significantly higher levels of both markers than the control group (median of LIGHT: 18.1 pg/ml vs. 7 pg/ml; p = 0.01; median of OSM: 10.3 pg/ml vs. 2.8 pg/ml, p < 0.001). Significantly lower serum level of LIGHT/TNFSF14 was found in nonsurviving patients ( n = 9) compared with survivors ( n = 51; p = 0.011). Based on ROC analysis, serum LIGHT/TNFSF14 with a cutoff value of >7.95 pg/ml predicted 30‐day survival with a sensitivity of 71% and specificity of 78% (Area: 0.763; 95% CI: 0.604–0.921, p = 0.013). In addition, it was also a predictor of DCI with a sensitivity of 72.7% and a specificity of 62.5% (AUC: 0.702; 95% CI: 0.555–0.849, p = 0.018). Based on binary logistic regression analysis, LIGHT/TNFSF14 was found to be independently associated with 30‐day mortality, but not with DCI. Conclusion In this cohort, a higher serum level of LIGHT/TNFSF14 was associated with increased survival of patients with aSAH.