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Self‐limited focal epilepsy decreased regional brain activity in sensorimotor areas
Author(s) -
Chen Liucheng,
Li Xiaofen,
Shen Longshan
Publication year - 2021
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/ane.13350
Subject(s) - epilepsy , audiology , cuneus , receiver operating characteristic , medicine , psychology , brain activity and meditation , area under the curve , postcentral gyrus , neuroscience , electroencephalography , functional magnetic resonance imaging , precuneus
Objective The fractional amplitude of low‐frequency fluctuation (fALFF) method was used to identify the regional brain activity deficits of self‐limited focal epilepsy with centrotemporal spikes (SLFECS) relative to normal controls (NCs). Methods A total of 21 SLFECS (10 females, 11 males; mean age, 8.57 ± 1.5 years) and 21 status‐matched (age, sex, and education) NCs (10 females, 11 males; mean age, 8.76 ± 2.19 years) were recruited. The fALFF method was applied to identify SLFECS‐related regional brain alterations. Receiver operating characteristic (ROC) curve was applied to identify the ability of these regional brain areas in distinguishing the SLFECS group from the NCs group. The relationships between the regional brain activity deficits and clinical features were evaluated by Pearson's correlation analysis. Results Self‐limited focal epilepsy with centrotemporal spikes was associated with widespread regional brain activity alterations, including left cuneus with higher fALFF values, and bilateral striatum, bilateral precentral gyrus, ventral and dorsal pathway of sensory area, left dorsolateral prefrontal cortex, and left Rolandic area with lower fALFF values. ROC curve revealed excellent AUC value (0.964) of these areas in distinguishing the SLFECS group from the NCs group with high degree of sensitivity (90.5%) and specificity (95.2%). Intelligence quotient score positively correlated with the fALFF value in the left striatum ( r = 0.453, p = 0.039). Conclusions The fALFF parameter could be served as a potential biomarker to identify the SLFECS‐related regional brain deficits in the sensorimotor cortex and their pathways, which may be the etiology of paresthesia in SLFECS.