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Transorbital ultrasonography for measuring optic nerve atrophy in multiple sclerosis
Author(s) -
Candeliere Merlicco A.,
Gabaldón Torres L.,
Villaverde González R.,
Fernández Romero I.,
Aparicio Castro E.,
Lastres Arias M. C.
Publication year - 2018
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/ane.12976
Subject(s) - multiple sclerosis , atrophy , ultrasonography , optic nerve , medicine , radiology , physical medicine and rehabilitation , ophthalmology , pathology , psychiatry
Objective we aimed to evaluate the utility of transorbital ultrasonography ( TOS ) in optic nerve assessment and quantification of ON atrophy in MS patients, and to determine whether ON atrophy correlates with the disease duration and disability measured on the Kurtzke Expanded Disability Status Scale ( EDSS ). Materials and methods Prospective, multicentre, blinded cohort study of 59 patients diagnosed with relapsing‐remitting MS and 36 controls. Results When measured with TOS , the diameter of both the right (2.69 ± 0.30 mm in cases; 3.20 ± 0.19 mm in controls, P < .0001) and left (2.71 ± 0.26 mm in cases; 3.24 ± 0.15 mm controls, P < .0001) ON of study patients was smaller than controls. We observed a negative correlation between EDSS and both right (ρ = .524) and left (ρ = .469) ON diameter. We also observed a negative correlation between disease duration and both right ( r = .602) and left ( r = .538) ON diameter. No difference was observed in the diameter of both ON among patients with a history of optic neuritis (right OND 2.68 ± 0.29 mm; left OND 2.69 ± 0.25 mm) and patients with no history of optic neuritis (right OND 2.70 ± 0.30 mm; left OND 2.73 ± 0.27 mm) ( P = .805; P = .651). Conclusions The thickness of ON measured with TOS is correlated with EDSS and the duration of the disease without being interfered by the previous history of optic neuritis. TOS could be a reliable technique for measuring ON atrophy in MS .